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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 17(1); 1974 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1974;17(1): 1-11.
An Experimental Study on the Effects of Acute Exposure to No<sub>2</sub> & So<sub>2</sub> Gases in the Respiratory Systems & the Other Organs of the Rats
Sang Yong Park, MD (Director : Prof. Man Kee Paik, MD, Hong Ki Kim, MD)
Department of Otolaryngology, College of Medicine, Seoul National University, Korea
二酸化窒素 및 亞黃酸가스 急性曝露가 白鼠의 呼吸器系 및 各 臟器에 미치는 影響에 關한 實驗的 硏究
朴祥用 (指導 : 金弘基, 白萬基 敎授)
서울大學校 醫科大學 耳鼻咽喉科學敎室
ABSTRACT

Nitrogen dioxide and sulfur dioxide are two major air pollutants. As it has been well known, the former is one of major components of photochemical oxidants and the latter plays indispensible role in London type smog accident. In the field of industrial toxicology, these two noxious gases are classified as irritant gas physiologically and many reports on the acute and chronic intoxication by these two gases have been filed. A strong irritating effect of these two gases on the epithelium of air way tract and the formation of methemoglobin by nitrogen dioxide has been ascertained as main toxic actions of these gases. Author designed this study to evaluate the value of hemogram, organ water contens and organ-body weight ratio as the quantitative indices for the physiological & pathological changes induced by the exposure to 100ppm, 500ppm & 1,000ppm of NO2 & SO2 gases for 4 hours. Following findings were observed : 1) In the NO2 exposure group, increase in the hemoglobin & hematocrit values was found and the degree of changes was proportional to the concentration of NO2 but the number of leucocytes was reduced. In the SO2 exposure group, a reduction of hemoglobin & hematocrit values was found and the degree of the changes was inversely proportional to the concentration of SO2 Leucopenia was found as in the NO2 exposure. 2) In the NO2 exposure group, water contents of the lungs and brain were increased and the reduction was found in the adrenal glands. The degree of changes were remarkable in the lungs and proportional to the concentration of NO2. In the SO2 exposure group, same trends were found as in the NO2 exposure except the brain which showed no changes. The degree of the changes were dominant in the NO2 exposure group than that of the SO2 exposure group. 3) Organ-body weight ratio was increased in the brain, lung, and heart in the NO2 exposure group and in the SO2 exposure group, the increase was observed in the lung alone and the reduction was found in the adrenal glands. The degree of the changes was proportional to the concentration in both NO2 & SO2 exposure groups.

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