The cause of esophageal cancer is still unknown in the majority of patients, but preexisting disease of esophagus related to the development of cancer were reported by many authors; e.g, lye stricutre, achalasia, plummer-vinson syndrome, dietary & alcoholic habits etc. Recently the authors had experienced one case of esophageal Ca. with complaint of dysphagia, developing at the site of lye stricutre, which was diagnosed by the esophagogram & esophagoscopic biopsy.