Nasal secretion has many small amounts of proteins. These proteins are composed of albumin, immunoglobulins, lysozyme, protease and protease inhibitors. In patients with allergy in the airways, it seems logical to carry out immunological investigations not only in the serum, but also in the secretion, produced locally in the shock organ. This study was performed to find out the variation of immunoglobulins in serum and nasal secretion among various nasal diseases. The authors collected sera and nasal secretions from 51 patients with acute rhinitis(6 cases), acute sinusitis(6 cases), chronic rhinitis(15 cases), chronic sinusitis(24 cases) and sera of normal healthy subjects(6 cases) were included as control in this study. The following results were obtained. 1) There was no statistically significant difference in the levels of serum IgA, IgG and IgM between various nasal disease groups. 2) The serum IgE level in the chronic rhinitis group with allergic nature was significantly higher than that in the chronic rhinitis group without allergic nature(p<0.05). 3) There was no statistically significant difference in the levels of IgG and IgM of nasal secretion between various nasal disease groups. 4) The IgE level of nasal secretion in the chronic sinusitis group with nasal polyp was significantly higher than that in the chronic sinusitis group without nasal polyp(p<0.05). 5) The IgA level of nasal secretion in the chronic sinusitis group was higher than that in the chronic rhinitis group(p<0.05). 6) There was no statistically significant difference in the levels of serum IgA, IgG, and IgM between groups classified by secretion nature. 7) The serum IgE level in the watery group was significantly higher than that in other groups. 8) There was no statistically significant difference in the levels of IgA, IgG, IgM and IgE of nasal secretion between groups classified by secretion nature.