Stenvens-Johnson syndrome is a reaction pattern, characterized by erythema multiforme of skin lesions, inflammation of mucous membranes and systemic toxicity usually in the form of fever and malaise. A wide varity of causing agents have been reported to be associated with bacterias, virus, drugs and chemicals. Authors experienced a Korean male patient considered as Stevens-Johnson syndrome, which cause was not able to be determined. However he was satisfactorily treated under admission and observation at out patient clinic.