Laryngeal papilloma is the most common tumor of the larynx, and it is often recurrent and difficult to cure. To date, surgical excision, irradiation, ultrasound, cryosurgery and various kinds of drug therapy such as antibiotics, hormones, vaccines, podophyllin, bleomycin, 5-FU etc., have been utilized. Recently, laser surgery and interferon therapy have been used by many surgeons. The authors reviewed 29 laryngeal papilloma cases which were treated with CO₂ laser surgery alone or a combination of CO₂ laser and interferon therapy.