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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 38(10); 1995 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1995;38(10): 1530-5.
Effects of Ruthenium Red on Plasma Extravasation in Neurogenic Inflammation in Rat Nasal Mucosa
Heung Man Lee, MD, U Seob Lee, MD, Hyo Yeol Kim, MD, Sang Hag Lee, MD, Geon Choi, MD, and Soon Jae Hwang, MD
Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine, Seoul, Korea
백서 비점막의 신경성염증에서 Ruthenium Red가 혈장의 혈관외유출에 미치는 영향
이흥만 · 이우섭 · 김효열 · 이상학 · 최 건 · 황순재
고려대학교 의과대학 이비인후-두경부외과학교실

Neurogenic inflammation is characterized by the vasodilation, plasma extravasation and edema formation due to released nueropeptide from the sensory nerve endings by the various stimulations such as capsaicin and electric stimuli. Ruthenium red is an inorganic polycationic dye which has a blocking effect on the cation channel in the sensory nerve terminals and has been considered as a blocker of the neurogenic inflammation. The purpose of this study is to investigate the effect of the ruthenium red on the neurogenic inflammation in the rat nasal mucosa induced by various stimulations. The amount of plasma extravasation was used as a parameter of the neurogenic inflammation and measured by the Evans blue extraction. Thr pretreated ruthenium red inhibited the effect of the capsaicin on neurogenic inflammation dose-dependently, but had no effects on the substance P and hypertonic saline-induced neurogenic inflammation. According to our results, ruthenium red might be utilized as a tool for the sensory neuron research and treatment of the nasal hyperreactivity.

Keywords: Neurogenic inflammationRuthenium redPlasma extravasation.
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