| Immunohistochemical Localization of Gentamycin Installed in the Guinea Pig Middle Ear Cavity |
| Chong Sun Kim, MD1, Ha-Won Jung, MD1, and Duk Hwan Lim, PhD2 |
| 1;Department of Otorhinolaryngology, College of Medicine, Seoul National University, Seoul, Korea, 2;Research Faculty(Senior Research Fellow) Beckman Laboratory Califorhia Institute of Technology Pasadena, Ca, USA |
| 기니픽 중이강에 투여한 Gentamycin의 내이분포와 내이독성에 관한 면역조직적 연구 |
| 김종선1 · 정하원1 · 임덕환2 |
| 서울대학교 의과대학 이비인후과학교실1;Research Faculty(Senior Research Fellow) Beckman Laboratory Califorhia Institute of Technology Pasadena, Ca, USA2; |
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| ABSTRACT |
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Investigations evaluating gentamycin(GM) in the inner ear were undertaken. Guinea pigs treated with 5mg/kg gentamycin sulfate on the round window niche(RWN) showed acute changes on electrocochleogram. Hair cell or microvilli damage on scanning electron microscopy(SEM), and accumulation of GM in the whole cochlea, on immunohistochemical study, were also seen. The GM remained in the cochlea especially in the organ of Corti and the type III fibrocytes after 24 hours. Immunolocalization of GM showed high affinity of GM for the hair cells and suggested some role of type III fibrocytes on excretion of GM in inner ear fluid.
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| Keywords:
GentamycinㆍImmunostainingㆍFibrocyteㆍInner ear. |
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