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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 39(5); 1996 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(5): 793-804.
A Study of Cathepsin D Expression Related to Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma
Jae Shik Cho, MD, Jong Shick Kim, MD, and Young Chae Yu, MD
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonnam National University, Kwangju, Korea
두경부편평상피암종의 Cathepsin D의 발현과 림프절 전이에 관한 연구
조재식 · 김종식 · 유영채
전남대학교 의과대학 이비인후-두경부외과학교실
ABSTRACT

Cathepsin D is a lysosomal aspartyl endopeptidase which degrade the extracellular matrix and proteoglycan. It is well known that tumor metastasis is a major prognostic factor in the survival & prognosis of the patient with head and neck cancer. This study was designed to investigate the relationship between cathepsin D expression and lymph node metastasis in head and neck squamous cell carcinoma, using immunohistochemical methods. Tissue were obtained from 50 patients with head and neck squamous cell carcinoma who underwent the surgery of primary tumor resection and radical neck dissection. The reults were as follows. 1) The positive reaction of cathepsin D was identified as characteristic granules both in carcinoma cells and extracellular matrix. The strong positive cathepsin D expression(2+ or 3+), as defined by cytoplamic immunoreactivity greater than 30% of the cancer cells, was found in 31 cases(62.0%). 2) Lymph node metastasis of patient wuth strong positive cathepsin D expression was 83.9%(26/31) compared with closely related with the lymph node metastasis(p=0.006). 3) Strong positive cathepsin D expression was noted in larger tumor size, increased number of metastatic lymph nodes and poorly differentiated histologic type(p<0.05). 4) Cathepsin D expression of the metastatic lymph nodes was stronger than that of the corresponding primary tumors(p=0.009). 5) There was no significant correlation between the patient age, clinical stage(TNM classification) and immunohistochemical detection of cathepsin D expression in head and neck squamous cell carcinoma. These results suggest that cathepsin D may be a biochemical parameter to predict the metastatic potential and aggressiveness of head and neck squamous cell carcinoma.

Keywords: Cathepsin DLymph node metastasisHead and neck cancerImmunohistochemistry.
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