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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 39(5); 1996 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(5): 814-24.
The Study on the Expression of IL-6 and ICAM-1 in Chronic Tonsillitis
Sung Min Chung, MD1, Ji Ae Lee, MD1, Ok Kyung Jung, MD1, and Sung Suk Kim, MD2
1;Department of Otolaryngology, 2;Pathology, College of Medicine, Ewha Womans University, Seoul, Korea
만성 편도염에서의 Interleukin-6와 Intercellular Adhesion Molecule-1의 발현에 관한 연구
정성민1 · 이지애1 · 정옥경1 · 김성숙2
이화여자대학교 의과대학 이비인후과학교실1;병리과교실2;
ABSTRACT

Interleukin-6(IL-6) is a multifunctional cytokine that regulates the immune response, acute phase reactions, and hematopoiesis. It is involved in induction of B-cell differentiation and induction of acute phase proteins. Intercellular adhesion molecule-1(ICAM-1) is an adhesion molecule expressed in high endothelial venules(HEVs) in humans, that is involved in the interactions between leukocytes and endothelial cells. ICAM-1 also plays a critical role during an inflammatory response in the interaction between activated endothelium and immunocompetent cells. Human tonsil specimens were stained by immunohistochemical method to compare the expression of IL-6 and ICAM-1 with the degree of tonsillar hypertrophy, age, and growth status. In addition, the correlation between eapression of IL-6 and ICAM-1 was studied. The results were as follows : 1) IL-6 was highly expressed on endothelial cells, plasma cells, and lymphocytes. 2) ICAM-1 was mainly expressed on lymphocytes in interfollicular areas and partially expressed on lymphocytes in germinal centers. 3) The expression of IL-6 and ICAM-1 was increased as the grade of tonsillar hypertrophy became high(p<0.05). 4) The expression of both IL-6 and ICAM-1 were slightly increased before puberty(p<0.05). 5) The expression of ICAM-1 was along as the exprssion of IL-6 became increased(p<0.05). This study showed that interaction of IL-6 and ICAM-1 was partly involved in tonsillar hypertrophy in recurrent tonsillitis of children.

Keywords: TonsilIl-6ICAM-1.
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