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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 39(11); 1996 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(11): 1907-12.
The Treatment of Sutton's Disease(Major Aphthous Stomatitis) with Colchicine
Hyung-Tae Kim, MD, Tae-Cheol Kim, MD, Min-Sik Kim, MD, and Seung-Ho Cho, MD
Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea
Colchicine 치료에 의한 Sutton's Disease(Major Aphthous Stomatitis)의 치험례
김형태 · 김태철 · 김민식 · 조승호
가톨릭대학교 의과대학 이비인후과학교실

Sutton's disease is characterized by long-standing and necrotizing ulcers of the oral mucosa that persist, remit and recur for variable periods of time. Despite the benign nature of the disease, persistent pain and unceration may disable patients form performing their daily activities. We describe two patients with Sutton's disease who were treated with short-term oral steroid and oral colchicine. In one patient, colchicine therapy was discontinued by himself but recurrence ocurred within several days. Then treatment with colchicine was restarted, a second remission was achieved within few days. At present, all patients experienced a marked decrease in symptoms and a remission of the disease. We review the literature on the subject and we conclude that colchicine therapy is an effective treatment for Sutton's disease.

Keywords: Sutton's diseaseMajor aphthous stomatitisColchicine.
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