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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 29(3); 1986 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1986;29(3): 306-28.
A Histopathological Study on the Pathway of the Inner Ear Involvement in the Experimental Pseudomonas Otitis Media
Jae Wook Hwang, MD1, Chan Il Park, MD1, Tai Kwon Cho, MD2, and Chong Sun Kim, MD2
1;Department of Otolaryngology, College of Medicine, Chungnam National University, 2;Department of Otolaryngology, College of Medicine, Seoul National University, Korea
實驗的 綠膿菌中耳炎에서 內耳侵犯經路에 관한 病理組織學的 硏究
黃在旭1 · 朴贊日1 · 趙泰權2 · 金宗善2
忠南大學校 醫科大學 耳鼻咽喉科學敎室1;서울大學校 醫科大學 耳鼻咽喉科學敎室2;
ABSTRACT

A histopathological study on the pathway of the inner ear involvement in experimentally produced Pseudomonas otitis media was done in 62 rats(Sprague Dawley). Otitis media was developed by inoculating Pseudomonas aeruginosa suspension(107/ml, 109 ml and 1011/ml) into the bulla through the tympanic membrane. In the period of 3 days to 12 weeks after inoculation, the pathways of the inner ear involvement and the histopathological findings of induced labyrinthitis were studied with light microscope. 1) The incidence of serous labyrinthitis was 29% in 109/ml and 7% in 1011/ml animal groups, and that of suppurative labyrinthitis was 4% and 40%. 2) The hemorrhage in perilymphatic spaces was found in 81%. And it was considered as a result of increased venous pressure in sacrification or thrombophlebitis due to osteitis. 3) The pathways in serous labyrinthitis was round window membrane in 6 cases and thrombophlebitis in 4 cases. 4) The pathways in suppurative labyrinthitis was round window membrane in 10 cases of temporal bones and thrombophlebitis in 1 case and cochlear aqueduct through meningitis in 2 cases. The inner ear pathology in acute stage of experimental otitis media was mainly present in perilymphatic spaces with moderate degrees, and that in chronic stage was in labyrinthine bony capsule, modiolus, internal auditory meatus, including cochlear turns.

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