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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 38(2); 1995 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1995;38(2): 252-7.
The Effect of Radiation therapy on Peripheral Blood Lymphocytes in Head and Neck Cancers
Sang-Yoon Kim, MD1, Hyo Joon Kim, MD1, Hee Jong Chang, MD1, Kwang Chol Chu, MD1, and Eun Kyung Choi, MD2
1;Department of Otolaryngology, 2;Radiation Therapy, College of Medicine, University of Ulsan, Seoul
두경부 악성종양 환자에서 방사선치료가 말초혈액 림프구에 미치는 영향
김상윤1 · 김효준1 · 장희종1 · 추광철1 · 최은경2
울산대학교 의과대학 이비인후과학교실1;치료방사선학교실2;

Radiotherapy(RT) is one of the most effective treatment modalities in head and neck cancers. However, the recent association of alterations in lymphocyte subpopulations and impaired cellular immunity prompted an investigation of the effects of RT on lymphocyte subsets in 28 patients with head and neck cancer. Percentage and absolute levels of CD3, CD4, CD8, CD16, and CD56 were respectively measured before RT, immediately after RT, 3 months, 6 months, and 112 months after RT. There were profound decrease in percentage and absolute level of CD3+ lymphocytes after RT, and these changes were still remained on 12th month after RT. The damage of CD4+ lymphocyte was more profound than CD8+ lymphocyte. Percentages of CD8+ lymphocyte and CD16+ and/or CD56+ cell(natural killer cell) were increased after RT, but absolute level of CD8+ lymphocyte was decreased and natural killer cell was not changed by RT. In conclusion, natural killer cell was most resistant to RT and CD4+ lymphocyte was most sensitive, and RT effects on peripheral blood lymphocytes were sustained for 12 months after RT.

Keywords: Head and neck cancerT-Lymphocyte subpopulationsNatural killer cellRadiotherapy.
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