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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 39(5); 1996 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(5): 747-53.
Cytokeratin Expressions of Induced Cholesteatoma in Gerbil
Keehyun Park, MD, Young-Myoung Chun, MD, and Hong-Joon Park, MD
Department of Otolaryngology, School of Medicine, Ajou University, Suwon, Korea
실험적 진주종의 사이토케라틴 발현양상
박기현 · 전영명 · 박홍준
아주대학교 의과대학 이비인후과학교실

Cholesteatoma is characterized by the presence of a keratinizing epithelium in the middle ear. The accumulation of desquamous epithelial cells appears to be a crucial factor in the pathogenesis of the middle ear cholesteatoma. The accumulation of the keratin debris is due to the migration, proliferation, and differentitation of basal keratinocytes. In the present study, we investigated the expression of specific cytokeratins in the experimental cholesteatoma in gerbil to determine whether any difference of differentiation and proliferation between cholesteatoma and normal skin using several specific cytokeratin. Cytokeratin expression patterns of induced cholesteatoma and deep meatal skin were characterized by the presence of hyperproliferative cytokertin, but cholestestoma showed more intensely hyperproliferative charateristics and some atypical variations. These suggest that extensive accumulation of keratinous mass in external meatus may induce changes in cellualr diffrentiation and proliferation.

Keywords: CytokeratinInduced cholesteatomaImmunohistochemistryMongolian gerbil.
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