Article information

Korean J Otorhinolaryngol-Head Neck Surg. 2021;64(12):932-936

Publication date (electronic) : 2021 July 2

doi : https://doi.org/10.3342/kjorl-hns.2020.00906

Ji Min Yun¹, Sunhee Chang², Yoon Kyoung So^,1

¹Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

²Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

윤지민¹, 장선희², 소윤경^,1

¹인제대학교 의과대학 일산백병원 이비인후과학교실

²인제대학교 의과대학 일산백병원 병리학교실

Address for correspondence Yoon Kyoung So, MD, PhD Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Paik Hospital, Inje University College of Medicine, 170 Juhwa-ro, Ilsanseo-gu, Goyang 10380, Korea Tel +82-31-910-7250 Fax +82-31-910-7518 E-mail hn0131@paik.ac.kr

Received 2020 October 5; Revised 2020 November 29; Accepted 2020 December 18.

Trans Abstract

Introduction

Collagenous fibroma (CF) is a rare, benign fibroblastic soft tissue tumor that classically presents as a non-tender, firm, slow-growing mass. This type of tumor was first described in 1995 by Evans [1], who coined the term ‘desmoplastic fibroblastoma,’ and was later renamed ‘CF’ by Nielsen, et al. [2]. The largest series of CF with 63 cases was published by Miettinen and Fetsch [3], who elucidated the clinicopathological features of the lesion. CFs predominantly occur within the subcutaneous tissue, but skeletal muscle involvement is common. They can occur at various sites, including arm, shoulder, back, extremities, head, and neck [3-10]. CFs are often omitted from differential diagnosis before surgery. In cases in which the mass develops at the site of a previous surgical wound, it can be mistaken for a recurrent tumor.

We report a unique case of CF that occurred at a previous surgical site after thyroidectomy for papillary thyroid carcinoma (PTC). Despite the rarity of CF, identification of this tumor is of diagnostic and therapeutic importance because it can be misdiagnosed as recurrent PTC, and surgery can risk damaging surrounding structures, including the recurrent laryngeal nerve (RLN).

Case

A 54-year-old male with a history of right-sided thyroid cancer presented with a mass that had been growing at a previous surgical site for one year. He had undergone right thyroid lobectomy for PTC through a cervical approach seven years prior at another hospital. At that time, lymph node dissection had not been performed. He had been taking levothyroxine 0.075 mg daily since the surgery. The patient detected a painless mass on his right anterior neck one year before presentation (six years after thyroidectomy). Ultrasonography (US) performed at the other hospital revealed a 2.7×1.8×3.0-cm-sized, hypoechoic mass at the thyroidectomy bed, and US-guided fine needle aspiration biopsy (FNAB) yielded fibromuscular tissue with no tumor cells. On follow-up US one year later, the mass increased in size to 3.2×2.2×3.8 cm, and the patient was referred to our hospital for further evaluation.

Physical examination revealed a 3.5-cm-sized, firm, non-tender mass around the previous thyroidectomy site in the right lower anterior neck. Vocal fold mobility was normal bilaterally, and there was no narrowing of the airway. Computed tomography (CT) scan demonstrated an approximately 4 cm, nonenhancing mass in the right thyroidectomy bed (Fig. 1). Enlarged cervical lymph nodes were not seen on CT. US showed a well-circumscribed, isoechoic mass at the right thyroidectomy bed in contact with the trachea (Fig. 1). US-guided FNAB was performed, but the needle barely penetrated the mass. The result of FNAB was non-diagnostic with no cellular component. Considering the radiological hypothesis of a benign soft tissue tumor and patient’s preference of surgical removal, authors scheduled a surgical excision rather than further radiologic or histologic evaluation, but we could not completely ruled out recurrent thyroid cancer preoperatively because of it’s location and rapid growing entity. With the patient under general anesthesia, the mass was excised with intraoperative monitoring of the RLN (Fig. 2). Considering potential adhesion to the previous thyroidectomy wound and the large size of the mass, we approached the mass from the lateral border of the right strap muscles. Grossly, the mass was firm, well-circumscribed, 3.5-cm-sized, and severely adherent to the adjacent sternocleidomastoid muscle (SCM) and strap muscles. The mass contacted the trachea but was easily dissected from it. Although the RLN was not identified during the operation, no sign of nerve injury was recorded with nerve monitoring. On pathologic examination, the mass was well circumscribed and hypocellular (Fig. 3). Within the tumor, a patternless distribution of bland spindle- or stellate-shaped cells was noted in a prominent collagenous-to-myxoid matrix. No mitotic figure or necrosis was found. The tumor cells did not show aberrant nuclear beta-catenin expression. The patient’s postoperative course was uneventful without complications, and vocal fold mobility was intact bilaterally.

Fig. 1.

Radiographic images of the tumor. On CT scan, an approximately 4 cm, ill-demarcated mass was observed at the right thyroidectomy bed (A-D). On an axial pre-enhanced CT scan, the mass showed the same density as the surrounding muscles (arrow, A). The outline of the mass is indicated with a dotted line (B). On contrast-enhanced CT scans, the mass was not enhanced (arrows; C, D). Rather, US (E) showed a well-circumscribed, isoechoic mass in contact with the trachea, although US-guided fine needle aspiration had no yield. US: ultrasonography.

Fig. 2.

Gross findings of the tumor. Grossly, the mass was firm, well-circumscribed, and 3.5 cm in size (A). The mass was located in the right thyroidectomy bed and severely adherent to adjacent sternocleidomastoid and strap muscles. It contacted the trachea but was easily dissected from it (B).

Fig. 3.

Microscopic findings of the tumor. The tumor was well-circumscribed and hypocellular (H&E stain, ×40) (A). The tumor showed a patternless distribution of bland spindle- and stellate-shaped cells in a prominent collagenous-to-myxoid matrix (H&E, ×200) (B). Neither mitotic figure nor necrosis was found. The tumor cells did not show aberrant nuclear expression on beta-catenin immunochemical stain (Beta-catenin, ×200) (C). H&E: hematoxylin and eosin.

Discussion

CF [2], previously known as desmoplastic fibroblastoma [1], is a rare benign fibroblastic/myofibroblastic neoplasm that most frequently involves the extremities and upper back [3]. Even rarer, it develops in the head and neck area, including the parotid, neck, and palate areas [4,6-10]. CF was reported to have a male predominance (51:12) and to have a peak incidence in the fifth and sixth decades of life [3]. Clinically, CF presents as a solitary, firm, well-circumscribed, painless and slow-growing mass of long duration. In majority of cases, no inciting event was clinically mentioned and no specific cause of a reactive fibrous proliferation was microscopically identified, suggesting that CFs represent neoplasms rather than reactive condition [1,2]. However, a history of antecedent trauma was previously noted in a few cases [3,6]. Since no case of CFs presenting at a postoperative site have been reported before, this case may indicate possibility of reactive condition involvement in development of CFs.

We report a unique case of CF that developed at a previous thyroidectomy site. CF can be a diagnostic challenge. The clinical features of the tumor in the present case, which occurred in the thyroidectomy bed from previous thyroid cancer and increased in size over 1 year, could have misled to diagnosis of recurrent thyroid cancer. Although both US and CT scans demonstrated benign tumor, recurrent thyroid cancer was not ruled out considering the indolent nature of differentiated thyroid cancers. Furthermore, the result of FNAB was non-diagnostic. Given the hypocellularity of the tumor, the FNAB result was low yield, and a core biopsy or incisional biopsy could have been more helpful. CF can also be a surgical challenge. Because the mass occupied the previous thyroidectomy site, revision surgery at this site risked damaging various vital structures, such as the RLN, trachea, esophagus, and surrounding neck muscles. According to recent reports, most CFs are located in the subcutaneous fat layer, but a muscular location is not rare (27%). Despite good demarcation, infiltration into fat or skeletal muscle was reported in most cases (78%) [3]. Also, there have been reports of neurologic deficits in cases of large CF [6,11-13]. Those can be worrisome characteristics for excision, especially in cases requiring revision surgery. In this case, the huge mass was severely adherent to the strap muscles and SCM. There was no adhesion to or invasion of the RLN, trachea, or esophagus. Postoperatively, there was no complication related to damage of surrounding structures.

CF is usually diagnosed postoperatively. Grossly, the tumor is well encapsulated and has a firm, homogeneous consistency. Microscopically, it is typically hypocellular with a highly collagenous or myxocollagenous matrix [5]. Uniform, spindle-to-stellate-shaped myofibroblasts scatter in fibromyxoid stroma, and mitotic activity is extremely low. All these pathologic features were observed in this case. The most important differential diagnosis for CF is desmoid-type fibromatosis (DTF), also called desmoid tumor. Microscopically, DTF is also characterized by spindle cells of uniform appearance with abundant collagen, but it is distinguished from CF by increased cellularity, poor circumscription, and an infiltrating border [14]. While CF has a benign nature and never recurs after simple excision, DTF is generally locally aggressive and recurs frequently. In addition to aggressive pathological findings in DTF, immunohistochemical staining for beta-catenin can help the differential diagnosis. Nuclear beta-catenin is reported to be positive in most, if not all, cases of DTF [14,15]. In this case, the tumor was hypocellular, and nuclear beta-catenin was negative. Other hypercellular fibrous tumors for differential diagnosis include fibroma of tendon sheath, calcifying fibrous pseudotumor, nodular fasciitis, and low-grade fibromyxoid sarcoma.

Another point of interest is the tissue of origin in this case. Since the tumor was adherent to the adjacent strap muscles and occupied thyroidectomy bed, we believe that in this case the tissue of origin could have been the strap muscles probably irritated by previous surgery. Previously reported case of CF involving thyroid gland suggested the prevertebral fascia surrounding the thyroid gland or carotid sheath as the possible origin [10].

Surgery has been the historical standard of treatment for CFs, and tumor recurrence after excision has not been reported [3]. Considering the benign nature of this tumor and lack of recurrence, conservative excision is recommended to minimize potential morbidity.

We described the unusual case of CF that developed at the surgical site of PTC. Because a soft tissue mass at the previous surgical site can be misdiagnosed as a recurrent tumor and CFs are difficult to be diagnosed with preoperative workups, it is clearly a diagnostic challenge. It may also pose a therapeutic challenge because it risks the injury of adjacent structures at the revision surgery of the thyroidectomy site. Despite these diagnostic and therapeutic difficulties, recurrence has not been reported after complete resection.

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