Article information

Korean J Otorhinolaryngol-Head Neck Surg. 2022;65(8):472-475

Publication date (electronic) : 2022 August 21

doi : https://doi.org/10.3342/kjorl-hns.2022.00563

Yujin Lee¹, Jeon Mi Lee², Hyun Jin Lee³, Gina Na², Sung Huhn Kim¹, Seong Hoon Bae^,1

¹Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea

²Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

³Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

이유진¹, 이전미², 이현진³, 나지나², 김성헌¹, 배성훈^,1

¹연세대학교 의과대학 이비인후과학교실

²인제대학교 의과대학 일산백병원 이비인후과학교실

³가톨릭대학교 의과대학 인천성모병원 이비인후과학교실

Address for correspondence Seong Hoon Bae, MD Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel +82-2-2228-3611 Fax +82-2-393-0580 E-mail bshsap1@yuhs.ac

Received 2022 June 23; Revised 2022 July 15; Accepted 2022 July 18.

Trans Abstract

Introduction

The clinical feature of Meniere’s disease includes fluctuating sensorineural hearing loss accompanied by aural pressure, tinnitus, and episodic vertigo. As an acute treatment for vertigo attacks, medical treatment such as antihistamine or anticholinergics is used. In contrast, chronic treatment for Meniere’s disease aims to reduce the frequency of vertigo attacks and prevent aggravation of ear symptoms. It starts with lifestyle modification such as reducing salt intake, avoiding caffeine and medical treatment including diuretics. If there is no response to drug, intratympanic corticosteroid (ITC) injection is generally considered as second-line treatment [1]. However, patients irresponsive to second-line treatment require tertiary treatment which commonly involves surgical intervention.

Chemical labyrinthectomy is a surgical procedure which ablates vestibular type 1 hair cells using aminoglycosides [2]. Direct application of gentamicin to the middle ear through explotympanotomy guarantees the accurate and sustained application of the drug compared to intratympanic injection of the solution. However, in both methods, the risk of hearing loss by gentamicin remains a main concern for clinicians because gentamicin ablates cochlear hair cells as well as vestibular hair cells. Half the patients treated with repetitive systemic high-dose aminoglycoside therapy suffered hearing loss at high-frequency level [3]. Hearing level can decline up to 31.08% after chemical labyrinthectomy with gentamicin depending on the administration and titration method [4,5].

Corticosteroid, including dexamethasone, can be used in sudden onset hearing loss or vertigo in various method of administration [6,7]. The effect of intratympanic dexamethasone injection in controlling Meniere’s disease is also previously reported [8]. To deal with the concern for hearing loss when using gentamicin, the dexamethasone can be combined with gentamicin during chemical labyrinthectomy [9]. The result of the combination method is promising in the preservation of highfrequency hearing although a small number of patients were enrolled.

Methods

Chemical labyrinthectomy procedures

After local anesthesia at external auditory canal, tympanomeatal flap was elevated to expose the oval window and round window. And then, gentamicin-soaked Gelfoam^® (Pfizer, New York, NY, USA) was applied to the oval window, and according to the patient group, saline-soaked Gelfoam^® or dexamethasone-soaked Gelfoam^® was applied to the round window (Fig. 1). A sufficient volume of Gelfoam^® should be applied to achieve the appropriate effect of drug administration. Using extremely small pieces of Gelfoam^® is recommended to prevent dead space in the round window niche. Meticulous bleeding control should be performed to prevent the mixing of two different drugs. Then, reposit tympanomeatal flap and apply Gelfoam^® on the incision site (Supplementary Video 1).

Fig. 1.

Endoscopic chemical labyrinthectomy was performed to a 53 years old female suffering from unilateral Meniere disease. (A) In the middle ear cavity, oval window and round window could be found (B) gentamicin-soaked Gelfoam^® (Pfizer) was applied to oval window (C) dexamethasone-soaked Gelfoam^® was applied to round window. Red arrow indicates oval window covered by stapes foot plate. Black arrow indicates round window niche.

Results

The hearing function was evaluated by pure tone audiometry (PTA) before the chemical labyrinthectomy and 2 months after the procedure. PTA thresholds were compared before and after surgery within each group. In GO group, PTA threshold in 4 kHz (p=0.005) and 8 kHz (p=0.012) frequencies were significantly increased after the chemical labyrinthectomy compared to PTA threshold before the procedure. However, in GD group, PTA threshold were not significantly changed in all frequencies, including in 4 kHz and 8 kHz (Fig. 2). In addition, it was compared whether there was a significant difference in the changed values of the PTA threshold for each frequency between the two groups. There is a significant difference (p=0.037) in PTA_high, especially in 4 kHz frequency threshold (p=0.049). Other parameters were not significantly different between two groups (Table 1).

Fig. 2.

Hearing functions before and after chemical labyrinthectomy. A: Pure-tone audiogram of GD group. B: Pure-tone audiogram of GO group. The high-frequency hearing thresholds (4 and 8 kHz) significantly worsened eight weeks after chemical labyrinthectomy only in the GO group. The black/hollow circles indicate median values. The error bars indicate the interquartile range. Wilcoxon matched-pairs signed rank test was used for analysis. ^*p<0.05; ^†p<0.01. GD, gentamicin combined with dexamethasone; GO, gentamicin combined with normal saline; Pre, before surgery; Post, eight weeks after surgery.

Table 1.

Changes in the results of PTA after chemical labyrinthectomy

Chemical labyrinthectomy using gentamicin combined with dexamethasone relatively preserved hearing at high frequency compared to the conventional method using gentamicin and normal saline. Vestibule is adjacent to oval window whereas scala tympani has no communication to the vestibular organ. Therefore, gentamicin applied on the oval window, as in this study, diffuses to the vestibule easily while dexamethasone applied on the round window diffuses to the cochlea more easily due to the anatomical structure [10].

Since both windows are located at the basal turn of the cochlea, the drug concentration would display a gradient from base to apex of cochlea, which corresponds to the tonotopical map of high to low frequency. High-frequency hearing is predicted to be more sensitive to drug administration for this reason [11]. As explained above, it is well known that steroids are effective in preventing hearing deterioration and controlling vertigo. Therefore, by applying dexamethasone to the basal turn of cochlear, it could be possible to prevent hearing loss at high-frequency according to the results of our study. Although the low-frequency hearing may also have been preserved by dexamethasone, it could have been hidden due to the low-frequency fluctuation, the feature of meniere’s disease.

Dexamethasone has been reported to have protective effect on gentamicin induced ototoxicity [12]. Despite the enigma of the exact mechanism of gentamicin-induced hair cell damage remains unsolved, the cell apoptosis pathway via reactive oxygen species formation is suggested to play a main role.

In conclusion, the direct administration of gentamicin combined with dexamethasone to the middle ear can preserve high-frequency hearing.

Supplementary Material

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