The prognosis of the advanced maxillary cancer is generally poor, especially when the lesions have already invaded the base of the skull at the time of diagnosis. The craniofacial resection was designed to provide en bloc removal of tumors involving the base of skull while protecting the frontal lobes from injury. The pericranium is dissected off the frontal scalp flap and is rotated into the anterior cranial fossa to serve as support for the blocking between cranial cavity and orbitonasal cavity. But under the situation of postoperative radiation, the pericranial flap is bound to be choose another word. In order to prevent possible cerebrospinal fluid leakage and secondary meningitis after radiation therapy, we designed the pedicled septal flap over the pericranial flap. The authors have recently experienced a case (maxillary cancer, stage IV) of craniofacial resection in which the surgical defect of the skull base was successfully repaired using the pericranial septal flap.