Histiocytic necrotizing lymphadenitis(HNL), or Kikuchi's disease, is of unknown origin, usually seen in young women and tends to spontaneous resolve. Authors report the clinicopathologic study about 3 patients, 1 male and 2 females, who were diagnosed as HNL on excisional biopsy and 1 female patient was suspected to be HNL on fine needle aspiration cytology but finally diagnosed as reactive hyperplasia on excisional biopsy. The common manifestations are cervical lymph nodes enlargement, fever, weight loss and night sweats. Laboratory investigations are usually non-contributary with an occasional case showing leukopenia or a raised erythrocyte sedimentation rate. HNL is not difficult to diagnosis once its characteristic histopathological features such as frank cellular necrosis, karyorrhexis and absence of plasma cells are recognized, however, there are no clinical features or laboratory findings which would allow a certain diagnosis to be made without biopsy. The later procedure is always required to establish the diagnosis, and to exclude other conditions such as malignant lymphoma and tuberculosis, for which specific treatment will be required.