Nasal mucosa is richly supplied with sensory and autonomic nerve fibers. Recent immunohistochemical studies have revealed nerve fiber containing substance P, calcitonin gene related peptides, neuropeptide Y, vasoactive intestinal polypeptide. It seems, therefore important to understand the functional significance of neuropeptides. First of all, we investigated the distribution of neuropeptides in nasal mucosa of the hamster using indirect immunohistochemistry(ABC method). Substance P and CGRP reactive fibers were seen beneath and within the nasal epithelium. NPY reactive fibers were seen around the blood vessels and glands, and VIP reactive fibers were seen around the blood vesseles.