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Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1988;31(3): 411-9. |
A Study of Changes in Serum IgE and IgG Values and Rhinomanometry after Hyposensitization in Nasal Allergy Patients |
Hong Soo Kim, MD, Min Soo Jang, MD, Chul Won Park, MD, Hyung Seok Lee, MD, Kyung Sung Ahn, MD, and Sun Kon Kim, MD |
Department of Otolaryngology, Han Yang University, College of Medicine, Korea |
비 알레르기 환자에 있어서 감감작요법 전후의 혈청 Ig E치, Ig G치 및 비강통기도의 변화에 대한 연구 |
김홍수 · 장민수 · 박철원 · 이형석 · 안경성 · 김선곤 |
한양대학교 의과대학 이비인후과학교실 |
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ABSTRACT |
As recent development of Immunology and Nuclear medicine, serum Ig E and Ig G values are helpful in diagnosis and evaluation of therapeutic effect of nasal allergy. Rhinomanometry was the most reliable method to evaluate the degree of nasal obstruction objectively and was helpful in determining the effectiveness of medical and surgical treatment. In 30 cases that were diagnosed as nasal allergy and treated with hyposensitization in Allergy Clinic of HanYang University Hospital, the author has observed changes in intradermal skin test, provocation test, eosinophil count in nasal secretion, serum Ig E and Ig G values, and rhinomanometry before and after hyposensitization. So the following results were obtained : 1) The size of erythema was markedly decreased over time until 12 months after hyposensitization, thence the change until 30 months was not significant. 2) The eosinophil in nasal secretion was decreased over time after hyposensitization. 3) The provocative reaction was markedly decreased over time until 12 months after hyposensitization and gradually decreased until 18 months, thence the change until 30 months was not significant. 4) The serum Ig E value at 30 months after hyposensitization was 403.2 I.U./ml compared with 428.5 I.U./ml before hyposensitization, 403.7 I.U./ml at 6 months, 409.4 I.U./ml at 12 months, and 390.3 I.U./ml at 18 months after hyposensitization, but the changes was not significant and the continuous follow-up will be considered. 5) The serum Ig G value at 30 months after hyposensitization was 1647.7 mg/dl compared with 1613.0 mg/dl before hyposensitization, 1667.3 mg/dl at 6 months, 1647.2 mg/dl at 12 months, and 1684.6 mg/dl at 18 months after hyposensitization, but the changes was not significant and the continuous follow-up will be considered. 6) The changes in rhinomanometry. (1) The mean total nasal resistance at 6 months after hyposensitization, 0.476
pa/cm3/sec(SD±0.190), was lesser than it before hyposensitization, 0.569
Pa/cm3/sec(SD±0.211). There was statistically significant difference of the mean total nasal resistance(p<0.01). (2) The mean total nasal resistance at 30 months after hyposensitization, 0.384
Pa/cm3/sec(SD±0.121), was lesser than it at 6 months after hyposensitization, 0.476
Pa/cm3/sec(SD±0.190). There was statistically significant difference of the mean total nasal resistance(p<0.01).
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