Mucormycosis is the preferred terminology to define a fungal disease which may be devastating and fatal. It is caused by a nonseptate hyphae, class phycomycetes and genus(Rhizopus, Mucor, Absidia). Mucormycosis in man is usually associated with debilitating disease such as : diabetes mellitus, leukemia and immunosuppressive conditions. The cephalic phycomycosis has two forms : 1) rhinoorbital cerebral which may be fatal, and 2) rhino-paranasal sinus form which usually has a benign clinical course. We experienced two cases of the mucormycosis recently. The one occurred in patient with liver cirrosis and nephrotic syndrome, the other in patient without underlying disease. The condition of the first patient deteriorated to death rapidly, but the second patient have a good condition after Caldwell-Luc operation and Amphotericin therapy.