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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 41(8); 1998 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1998;41(8): 984-987.
DPOAE in Acoustic Neuroma.
Hyuk Kim, Tae Hyun Yoon, Jong Woo Chung, Kwang Sun Lee
Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. kslee2@amc.seoul.kr
청신경종양 환자에서의 변조이음향방사 측정
김 혁 · 윤태현 · 정종우 · 이광선
울산대학교 의과대학 서울중앙병원 이비인후과학교실
주제어: 변조이음향방사청신경종양.
ABSTRACT
BACKGROUND:
Evoked otoacoustic emissions (OAEs) are assumed to reflect healthy outer hair cell function. It is possible that these objective tests can provide some insight into the fundamental basis of the hearing loss exhibited by patients with acoustic neuromas. The primary aim of the present study was to examine the effects of acoustic neuromas on the amplitudes of evoked OAEs and to compare these findings with tumor-induced hearing levels.
MATERIALS AND METHODS:
The amplitude and growth functions of distortion product otoacoustic emission (DPOAE) at 2f1-f2, elicited by two primary tones f1 and f2 with a constant frequency ratio f2/f1=1.22 and varing geometric mean values 0.5, 1, 2, 4, and 8 kHz, were measured for 13 patients with radiologically proven acoustic neuroma.
RESULTS:
After comparing audiograms and DP-gram, we found four patients with neural hearing loss, seven patients with sensory (cochlear) hearing loss, and two patients with sensorineural (mixed) hearing loss. There was a strong correlation between the results of DPOAE and the tumor location or duration of symptom, whereas there was no correlation between tumor size and cochlear function.
CONCLUSION:
DPOAEs can identify preoperatively the sensory (cochlear) components of hearing loss induced by an acoustic neuroma. These emissions are also useful with a battery of retrocochlear screen tests, but they could not be relied on solely to rule out central hearing disorders.
Keywords: DPOAEAcoustic neuroma
서론 이음향방사(otoacoustic emission)는 와우 외유모세포의 능동적인 미세진동에 의해 발생하여 중이를 거쳐 외이도로 전파되어 나타난다. 이는 외유모 세포의 기능과 밀접한 관계를 가지며 와우의 기능을 반영한다. 특히 변조이음향방사(distortion product otoacoustic emission, 이하 DPOAE로 약함)는 와우의 비선형성의 또 다른 증거로 두 개의 다른 주파수를 갖는 f1, f2 (f1REFERENCES
1) Levine RA, Ojemann RG, Montgomery WW. Monitoring auditory evoked potentials during acoustic neuroma surgery. Insights into the mechanism of the hearing loss. Ann Otol Rhinol Laryngol 1984;93:116-23. 2) Bonfils P, Uziel A. Evoked otoacoustic emissions on patients with acoustic neuromas. Am J Otol 1988;9:412-7. 3) Ohlms LA, Lonsbury-Martin BL, Martin GK. Acoustic distortion products: Separation of sensory from neural dysfunction in sensorineural hearing loss in humans and rabbits. Otolaryngol Head Neck Surg 1991;104:159-74. 4) Seo YI, Yoon TH, Won JY, Chung JW, Lee KS. Distortion product ot-oacoustic emissions in normal and sensorineural hearing loss ears. Korean J Otolaryngol 1997;40:1197-204. 5) Telischi FF, Roth J, Stagner BB, Lonsbery-Martin BL, Balkany TJ. Patterns of evoked otoacoustic emissions associated with acoustic neuromas. Laryngoscope 1995;105:675-82. 6) Kemp DT, Bray P, Alexander L. Acoustic emissions cochleography-practical aspects. In: Cochlear Mechanics and Otoacoustic emissions. Cianfrone G, Grandori F (Eds). Scand Audiol (Suppl. 25) 1986:71-96. 7) Lonsbury-Martin BL, Martin GK. The clinical utility of distortion product otoacoustic emissions. Ear Hear 1990;11:90-9. 8) Perlman HB, Kimura R, Fernandez C. Experiments on temporary obstruction of the internal auditory artery. Laryngoscope 1959;69:591-613. 9) Oeken J. Assesment of cochlear function with distortion products of oto-acoustic emissions in acoustic neuroma. HNO 1996;44:677-84. 10) Thomsen J, Tos M. Diagnostic strategies in search for acoustic neuromas: Findings in 300 neuroma patients. Acta Otolarygol Suppl (Stochk) 1988;452:16-25. 11) Nadol JB, Levine R, Ojemann RG. Preservation of hearing in surgical removal of acoustic neuromas of the internal auditory canal and cerebellar pontine angle. Laryngoscope 1987;97:1287-94.
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