Malignant tumor of the nose and nasal cavities are 2.39% of all malignant tumors in Korean. Primary nasal septal tumors are very rare. Recently we experienced a rare case of spuamous cell carcinoma originating from nasal septum of 42 years old male patient. He was treated with transpalatal resection, anticancer drug, and Co radiation therapy. We report this patient's clinical course and treatments.