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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 39(5); 1996 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(5): 776-82.
Therapeutic Effects of Topical Drug Delivery System Using Antibiotic-Polylatic Acid Polymer on Experimentally Induced Paranasal Sinusitis in Rabbits
Yang-Gi Min, MD1, Hae Song Kim, MD2, Chae-Seo Rhee, MD1, Won Ho Chung, MD1, Kang Soo Lee, MD1, and Jae Koo Kang, MD1
1;Department of Otorhinolaryngology College of Medicine, Seoul National University, Seoul, 2;Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonnam National University, Kwang Ju, Korea
실험적으로 유발시킨 가토 부비동염에서 항생물질-Polylactic Acid 폴리머를 이용한 국소약물전달 체계의 치료효과
민양기1 · 김해송2 · 이재서1 · 정원호1 · 이강수1 · 강제구1
서울대학교 의과대학 이비인후과학교실1;전남대학교 의과대학 이비인후과학교실2;
ABSTRACT

The aim of this study was to assess the therapeutic effects of antibiotic delivered by polyactic acid (PLA) polymer in sinusitis. Maxillary sinusitis was induced in 27 New Zealand white rabbits by occluding the sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae serotype 3. The rabbits were divided into 3 groups consisting of group 1 (control group, 9 rabbits) that was treated only by reopening the ostium only, group 2 that was treated by both reopening the ostium and injecting ampicillin intramuscularly (9 rabbits), and group 3 (9 rabbits) in which a piece of PLA-polymer ampicillin sheet was placed within the sinus after reopening the ostium. The histologic findings including epithelial ulceration, loss of cilia, infiltration of inflammatory cells, and edema were mild to moderate in group 2 and minimal in group 3. The ultrastructual findings including swelling of mitochondria and endoplasmic reticulum, and protruded cytoplasm were severest in the control group, followed by groups 2 and 3. The mucociliary transport speed measured at the medial wall of the maxillry sinus was highest in group 3. The results of this study suggest that treatment with PLA-polymer ampicillin may have better therapeutic effects in maxillary sinusitis than that with systemic administration of ampicillin.

Keywords: Polylactic acid polymerDrug delivery systemMucociliary transport speedSinusitis.
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