Nasal Mucosal Hypersensitivity according to the Change of Temperature in Allergic Rhinitis |
Hyoung Kwan Joo, MD, Jeung Gweon Lee, MD, Joo Heon Yoon, MD, Kwang Moon Kim, MD, and Young Seok Chung, MD |
Department of Otorhinolaryngology, Yonsei University College of Medicine, Korea |
알레르기성 비염환자에서 온도자극에 따른 비점막 과민 현상에 대한 연구 |
주형관 · 이정권 · 윤주헌 · 김광문 · 정영석 |
연세대학교 의과대학 이비인후과학교실 |
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ABSTRACT |
Cold stimulation is known to induce nasal obstruction and accelerate the degree of nasal symptoms in patients with allergic rhinitis. The purpose of this study is to evaluate nasal mucosal response to temperature stimulation in patients with allergic rhinitis, by means of nasal airway resistance(NAR). The subjects are 15 patients with allergic rhinitis and 30 healthy adults. For caloric stimulation, nasal vestibule was stimulated with Copper stick of different temperature, feet with water of different temperature in Paraffin heater, i.e., 22, 43, 0 centigrade for one minute. NAR was measured before stimulation, and 2, 15, 30 min after stimulation by STD Rhino KOC-8900(Chest Co. Japan) rhinomanometry with anterior active method. The change of NAR after each stimulation on nasal vestibule was greater than that on feet in both groups. NAR was increased after cold stimulation on nasal vestibule in both groups(p<0.05). The rate of change in NAR after cold stimulation on nasal vestibule in allergic rhinitis was more steep than in control(p<0.05). This results suggest that the patients with allergic rhinitis has hypersensitivity of nasal mucosa to cold temperature especially because of antigen-antibody reaction.
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