Authors made a statistical analysis of biopsies performed on 607 cases who visited the Dept. of Otolaryngology, Korea General Hospital, during past 13 years. Anatomical classification of histopathologic data was based on the American Joint Committee on Cancer Staging(1980). Through the analysis, results obtained were as follows : 1) Among the total of 607 cases of biopsy, 136 cases (22.4%) were inflammation, 277 cases(45.6%) were tumor, and 194 cases(32.0%) were non-neoplastic tumor. The tumor cases consisted of 99 cases(35.7%) of benign tumor and 178 cases(64.3%) of malignant tumor. 2) In the sex distribution of tumors, there were 140 cases(78.7%) of male and 38 cases(21.3%) of female for malignant tumors, and there were 59 cases(59.6%) of male and 40 cases(40.4%) of female for benign tumors. 3) In the age distribution of tumors, there were 154 cases(86.5%) of malignant tumors in the aged group above forty, and 80 cases(80.8%) of benign tumors in the young age group below forty. 4) Of malignancy(178 cases), the pharynx was the most frequent site of regional incidence showing 49 cases(27.5%), and the larynx : 41 cases(23.1%), the nose and paranasal sinuses : 28 cases(15.7%), and the oral cavity : 27 cases(15.2%) in order of frequency. 5) Of benign tumors(99 cases), the oral cavity was the most frequent site of regional incidence showing 31 cases(31.3%), and the pharynx : 26 cases(26.3%), the larynx : 22 cases (22.2%), and the nose and paranasal sinuses : 14 cases(14.1%) in order of frequency. 6) The most common malignant tumor was squamous cell carcinoma(127 cases ; 71.4%), and malignant lymphoma(18 cases ; 10.1%) was next in order. 7) The most common benign tumor was papilloma(63 cases ; 63.6%), and hemangioma(12 cases ; 12.1%) was next in order. 8) The non-neoplastic tumor(pseudo tumor) consisted of 144 cases of laryngeal polyp or vocal nodules, 22 cases of nasal polyp and 28 cases of cyst, which were distinguished from the true tumor or the inflammation. 9) Of inflammation(136 cases), the oral cavity was the most frequent site of regional incidence showing 54 cases(39.7%), and chronic non-specific inflammation was the most frequent histopathologic type(83 cases ; 61.0%).